Site-specific DICER and DROSHA RNA products control the DNA-damage response
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چکیده
منابع مشابه
Nuclear phosphorylated Dicer processes double-stranded RNA in response to DNA damage
The endoribonuclease Dicer is a key component of the human RNA interference pathway and is known for its role in cytoplasmic microRNA production. Recent findings suggest that noncanonical Dicer generates small noncoding RNA to mediate the DNA damage response (DDR). Here, we show that human Dicer is phosphorylated in the platform-Piwi/Argonaute/Zwille-connector helix cassette (S1016) upon induct...
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The number of factors known to participate in the DNA damage response (DDR) has expanded considerably in recent years to include splicing and alternative splicing factors. While the binding of splicing proteins and ribonucleoprotein complexes to nascent transcripts prevents genomic instability by deterring the formation of RNA/DNA duplexes, splicing factors are also recruited to, or removed fro...
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Affiliation: Graduate Institute of Life Science, National Defense Medical Center, Taipei 115, Taiwan Genomics Research Center, Academia Sinica, Taipei 115, Taiwan 3 PNN technologies Inc, Woodbridge, VA 22195, USA Department of Pediatrics/Hematology-Oncology, University of California San Diego Medical Center, CA 92103-8447, USA Children's Oncology Group Statistics and Data Center, University of ...
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It is widely accepted that tumorigenesis is a multistep process characterized by the sequential accumulation of genetic alterations. However, the molecular basis of genomic instability in cancer is still partially understood. The observation that hereditary cancers are often characterized by mutations in DNA repair and checkpoint genes suggests that accumulation of DNA damage is a major contrib...
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RNA viruses are a genetically diverse group of pathogens that are responsible for some of the most prevalent and lethal human diseases. Numerous viruses introduce DNA damage and genetic instability in host cells during their lifecycles and some species also manipulate components of the DNA damage response (DDR), a complex and sophisticated series of cellular pathways that have evolved to detect...
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ژورنال
عنوان ژورنال: Nature
سال: 2012
ISSN: 0028-0836,1476-4687
DOI: 10.1038/nature11179